The senior All-American had 27 points to pass Angel McCoughtry as the Big East's all-time scoring leader as No. 2 UConn routed Oklahoma (No. 12 ESPN/USA Today, No. 14 AP) 86-45 on Monday night.
"It's the icing on the cake because if we had come out and played really poorly, it would be really hard to celebrate," she said.
Moore needed 11 points to pass the former Louisville All-American, who scored 2,779 points from 2006-2009. Moore drove the lane and made a one-handed scoop shot with her right hand to set the record with 7:52 left in the first half.
"There's nobody else like Maya in the country," UConn coach Geno Auriemma said. "When she's playing like that everyone else feels like they can get involved as well."
She also moved past McCoughtry into 16th place on the career NCAA Division I scoring list. Jackie Stiles, who played at Southwest Missouri State from 1998-2001, is the career scoring leader at 3,393 points.
Moore scored 18 of her points in the first half, helping Connecticut build a 46-18 lead at the break. She finished 12-for-18 from the field with seven rebounds, seven assists and six steals.
"Maya is an amazing person to watch," UConn teammate Lorin Dixon said. "She rightfully deserves everything she gets. I'm in awe of her."
Connecticut (25-1) won its 14th straight game overall and 76th straight at home.
Stefanie Dolson had 15 points and nine rebounds for the Huskies, Tiffany Hayes scored 13 points and had seven rebounds and Bria Hartley added 11 points.
Danielle Robinson led Oklahoma (18-7) with 14 points and Nicole Griffin added 10.
UConn shot 56 percent from the field (36-for-64) and held Oklahoma to 30 percent (19-for-64). The Huskies outrebounded Oklahoma 49-28.
"UConn had competitive fire on every possession and I am embarrassed," Oklahoma coach Sherri Coale said. "I am embarrassed by our lack of fight. In 15 years, I have to say that this is the worst loss."
It was actually Oklahoma's biggest defeat since losing to Stephen F. Austin 106-54 on March 8, 1978, in the Southwest AIAW Championship.
UConn made 20 of 32 shots in the first half and led by scores of 14-4, 23-6 and 35-8. Carlee Roethlisberger's 3-pointer with 4:53 left in the half got the Sooners within 37-13, the closest they had been since trailing 27-6 five minutes earlier.
"The way we came out ot start this game was incredible," Moore said. "Everyone had a lot of energy. Couldn't have asked for a better effort from my team.
The Sooners shot 25 percent from the field in the first half and missed 12 of their 13 3-point attempts.
"[UConn] has three people diving after loose balls and there wasn't one [Oklahoma] jersey on that side of the floor," Coale said. "That's the stuff that drives me crazy."
Dixon fed Moore a pass along the baseline which led to a layup and give UConn a 23-6 lead with 9:14 left in the first half. UConn made 10 of its first 16 shots (63 percent).
Hayes made two free throws with 12:52 left in the first half to cap an 8-0 run and give Connecticut a 14-4 lead. The Sooners missed 14 of their first 17 shots.