The Bears (4-2) never trailed in the contest and took an early 1-0 lead in the 12th minute.
"I commend Missouri State for the passion they played with tonight," said OU Head Coach Nicole Nelson. "We lacked focus on two set pieces and it cost us the game. Lack of discipline is something that we can control and will.
"We gave up a goal early and felt sorry for ourselves. Moving forward, we will continue to work on starting games with the grit and fight that we were so proud of on Sunday (against Colorado College)."
Senior forward Whitney Palmer scored in her second straight game and tied the score at one goal apiece in the 21st minute.
However, the home team regained the one-goal advantage seven minutes later as the OU defense surrendered an own goal which proved to be the difference.
Missouri State jumped out to a 3-1 lead after tallying a goal midway through the second half.
The Sooners got back to within one as freshman Zoe Dickson tallied her first career goal.
Dickson’s goal in the 82nd minute made it 3-2 but it wasn’t enough as OU lost for the first time since the season opener at then-No. 19 Oklahoma State on Aug. 20. Sophomore Dria Hampton and freshman Amy Petrikin assisted on the Sooners’ second and final goal.
Despite leading the shot count, 14-11, and holding the lead in corner kicks, 11-7, OU was unable to improve to 4-0 all-time against Missouri State.
Oklahoma won each of the three previous meetings in the series with Missouri State, including last year’s contest played during the season opener in Norman. Friday night’s game was the first meeting in the series played in Springfield, Mo.
The Sooners return home to host Rice on Sunday, Sept. 12 at 1 p.m. Fans that present their football ticket stub from the OU vs. Florida State game will receive $4 admission.